Pages

Labels

12th anniversary 21st Amendment Monk's Blood Abbaye De Saint Bon Chien abhyasa abuse abyss active vs. passive poses acute pain agility agitated depression ahimsa Al-Aksir alasya ale alesmith alignment Allagash anatomy Anchor Brewing Anchor Brewing Company anchor steam Anchor Steam Brewing and moderation Andrea Gilats Angel's Share anger ankle circles ankle injuries ankle joint ankle problems ankle sprains anti-aging solution anxiety aparigraha appetite arm pain arm strength arms arthralgia arthritis arthritis (menopause) arthritis of shoulder joint atrial fibrillation avery avery maharaja award winning beer store ayurveda B.K. Bose baba back care back extensor muscles back pain balance Ballast Point baltic thunder bandhas bandwagon of healthy eating baroreceptors basque cider Baxter Baxter Bell bay area beer beer beer advocate beer castro beer club beer club san francisco beer list Beer of the Month beer of the month club beer pong beer shop san francisco beer store Belgian beer belgian beer glasses belgian beer san francisco Belgium. Japanese best beer store in the world BFM Bhagavad Gita Bhramari Bikram Choudhury biological clock Birra Troll Birrifio bitches brew Bittersweet Lenny black butte black lager blood lactate blood pressure body image bone strength Bonnie Maeda bottle bag bourbon Brad Gibson brain strength Brasserie Caracole breath breath practices Brettanomyces Beer Brewing Bridge pose Bridget Frederick Bruery Coton Bruery Mischief Bruery Saison De Lente bruising Brussels Bruton beer bursitis bypass surgery California beer Callifornia beer caloric restriction Cantillon cantillon san francisco Carol Krucoff cascade apricot cascade sang rouge cask strength sake Castro Cat pose Cat-Cow pose cataracts central nervous system cervical nerves Chair Cat pose Chair Downward-Facing Dog pose Chair Purvottansana chair yoga chair yoga sequence challenging pose charlie papazian chatoe rogue cheese Child's pose children Chimay chimay san francisco chocolate indulgence chondromalacia christmas beer chronic illness chronic inflammation chronic pain chronic stress cognitive decline cognitive health collapsed lung commenting comments community community yoga compassion compression of joints connective tissue conscious relaxation contacting writers contentment cortisol counter-poses Cow pose craft beer craft beer san francisco craft beer store craft brew creaky knees Cucapa Barley wine Cuvee de Tomme Cuvee des Champions Damnation dave hauslein david hausein David Hauslein Dayna Macy De Dolle De Proef De Ranke Dead Guy Ale Decadence Pomegranite Saison Decadent Evil degenerative disc disease dementia dental disease depression Depuceleuse san francisco DFH Faithful Ale DFH Twenty dharana dhyana dhyanam diabetes diet digestion digestive disorders digestive system dogfish head Dogfish Head Theobroma Dolphin pose dominus vibiscum doshas double ipa Downward-Facing Dog pose Downward-Facing Dog pose (variations) drake's denogginizer Drie Fontinen duck feet Eagle pose Easy Inverted Pose eating habits eating healthy Einbecker El Camino (un) real emotional wellbeing endorphins endurance training enteric brain equanimity eric's ale European Society of Cardiology exercise extensor muscles eye floaters eye problems facebook beer Fantome fatigue feet felt real happiness fifty fifty brewing company Firestone Walker first growth first trimester fizzy yoga Flanders flat feet Flemish Primitive flemish sour ale flexibility Food pyramid guide forehead skin forward bends fred echardt front body frozen shoulder full sail topsail fun gait Gandhi ganglion cysts Garudasana genetics Georg Feuerstein George Gale ginjo Gonzo goose island goose island san francisco Goouden Carolus gouden carolus Grand Cru greed grief grow your own Gueuze gueuze girardin Haandbryggeriet hakutsuru Halasana (supported) hands Handstand Hanssens lambic happiness hard cider head position head rush headaches health care professionals healthy aging healthy eating Healthy Eating Ideas healthy spirits healthy spirits Mikkeller 1000 IBU healthy spirits san francisco healthy spirits. Deschutes Jubel Ale 2010 healthy spirits. san francisco healthy spirits. san francisco beer healthy spriits healthy style of eating heart problems Hedonist Beer Jive herbs hernias high blood pressure himsa Hinduism hip arthritis hip dysplasia hip replacements history of yoga Hitachino Nest Hitachino XH hoarding home brew home practice home yoga practice hop wallop Howe Sound Hugh Malone hummus hypertension hypotension ida immune system inflammation inguinal hernias injuries insomnia Inverted Lake pose Irritable Bowel Syndrome Jalandara Bandha Japanese beer jatharagni jay hinman jizake John John joint health joint pain joint replacement joints Jolly Pumpkin Jon Kabat-Zinn Judith Lasater kampai karma yoga karuna Kausthub Desikachar kidney kleshas knee alignment knee joint knee pain knee replacement Koningshoeven Krishnamacharya Krishnmacharya kundalini lactic acid lager Lambic large women leg cramps leg length discrepancy (LLD) Legs Up the Wall pose life coaching Life Coaching Executives Life coaching problems ligaments lips of faith longevity Lost Abbey Lost Abbey Brewing Company low back low back pain low blood pressure Luciernaga Lucifer lying male hormones male menopause malnutrition Man Bites Downward-Facing Dog marijuana marin brewing barrel aged old dipsea massage medical advice medical conditions (informing teacher of) medical conditions (yoga for) meditation Melina Meza Melitta Rorty men menopause mental health Mephistopholes micro brew micro-brew middle-eastern Midnight Sessions Lager Midnight sun brewing midnight sun hop dog midnight sun san francisco migraines Mikkeller Mikkeller Beer Geek Breakfast Mikkeller Black Mikkeller chipotle porter mind-body connection mindful yoga mindfulness mini office yoga sequence mini yoga practices miracle mission statement mood Morton's Neuroma motivation Mountain pose Multiple Sclerosis Muriel Zimmerman music nadis napa smith nate breed neck anatomy neck pain neuroma neuropsychiatric disorders new arrivals new belgium new releases nigori Nina Zolotow Niroga Institute noble pils nocturnal leg cramps Nogne-O non-hoarding non-violence Norwegian beer nutrient-dense foods oak aged oak aged ale oatmeal stout Odonata Rorie's Ale odonata saison office yoga Old Inventory Barleywine ommegang Ommegeddon oral hygiene Orval osteoarthritis osteopenia osteoporosis Oyster Stout pain pain management parabola partner yoga Paschima Namaskarana Paschimottanasana passive vs. active poses Patricia Walden Paul Grilley peanuts Pearl Jam Pearl Jam Beer pelvis perimenopause pes planus philosophy physio-yoga pigeon toes pingula pinto plantar fascitis Pliny the Elder Pliny the Younger Plow pose (supported) pneumothorax Port Brewing postural control posture Powerful pose practice practice (changing your) prana prana vayu pranayama pratipaksha bhavanam pregnancy private lessons proprioception psoas Puppy pose purusathas Purvottanasana Purvottansansa quadruppel questions R. Sriram Ram Rao rami barqawi Rami's Mommy's range of motion (ROM) rate beer ratebeer real ale Reclined Cobbler's pose red lentils Redemption relaxation Relaxation pose relaxation response religion (and yoga) resistance training resting restless leg syndrome restorative backbend restorative yoga retreats Reverse Prayer pose Richard Rosen Rodenbach barrel 230 Rogue Brewery Russian River Russian River Sanctification sacroiliac joint sacrum sacrum (anatomy of) safety saint somewhere saison Saison Du BUFF sake Salvation samana vayu samaranth san francisco san francisco Beer San Francisco beer store San Francisco Beer Week san francisco bottle shop san francisco craft brew san francisco fantome san francisco odonata santosha Sarah Powers Sarvangasana (supported) satya saucha Savasana scalene muscles scar tissue Schaerbeekse Kriek Schlenkerla Ur-Bock Schneider scientific studies Sculpin sedentary behavior Seedstore seniors sequencing Setu Bandha Shari Ser shochu shoulder blades shoulder joint (arthritis of) shoulder joint replacement shoulders shoulders. sequences Shoulderstand (supported) sierra nevada sierra nevada 30th anniversary Signature Ale sitting-rising sleep smiling soy speedway stout spiritual health spiritual wellness split peas squatting steenbrugge stem cell regeneration stillwater Stone stone brewing company stopping yoga practice store hours beer strength stress stress management stress response Stretching stroke strong cheese styana suffering Sukasana supplements Supplication Supported Child's Pose Supported Forward Bend Supta Badha Konasana surgery sushumna nadi Swiss beer Table pose tabouli Tadasana teacher (choosing) teachers teaching seniors Temptation testosterone Thanksgiving Thanksgiving Day Schedule The abyys san francisco The Bruery Thoracic Outlet Syndrome Thoreau tilting the pelvis timing poses Timothy McCall top sail toronado total knee replacement towards healing and finding the solution transferring transitions trappist trauma trial run coaching session truth tucking the pelvis TV Twilight and Life Coaching ujjayi breath unfiltered sake unibroue Upavista Konasana upper body flexibility upper body strength Upward Plank pose Upward-Facing Plank pose urthel Utkatasana val dieu Valley Brewing Company variety vata vayu vegetarian way vertical epic vestibular system victory Victory at Sea viloma breath vintage beer violence Viparita Karani vyana vayu Warrior 1 Warrior 2 pose Warrior 3 wedge weight loss weight management wild ale wild devil will power William Broad workshops wrist problems wrists wu tang clan xyauyu yamas Yin Yoga yoga history Yoga Journal conference yoga nidra yoga philosophy yoga sutras yoga therapy yogic breathing yogic phases of life yulesmith summer

Thursday, September 6, 2012

Caloric Restriction: Comment and Response

by Nina and Brad

Brad’s post on caloric restriction (see Caloric Restriction and Longevity) prompted an interesting comment from Kathleen Summers MD PhD that I thought it worthwhile to share with you. Rather than having Brad respond in the comments section (I'm not sure how many of you actually read the comments), I asked him to reply to her comment at the end of this post. So have a look! This debate is a very good example of how little scientists currently understand about the aging process (a theme we return to periodically) and provides a hint of some of the many issues surrounding the controversy regarding the best diet for healthy aging.

Posted by Kathleen Summers MD PhD to YOGA FOR HEALTHY AGING

The biggest lesson here is that an excess of energy intake brings disease, disability, and early death. Restricting intake protects against cancer - and also diabetes, arthritis, and heart disease to some degree, although the numbers in the latest study didn't reach significance for the latter (potentially due to limited sample size). Teasing out just what the optimal amount of intake is takes time and research. And it's complicated - there's nutritional, environmental, mental/emotional health, and genetics among other factors playing a role.

The monkeys in both groups of the Wisconsin study ate more and weighed more than the NIH monkeys. The researchers used different sources for their proteins, fats, and carbs as well as a different approach to vitamin and mineral supplementation.

We have one primate study showing extended life span with calorie restriction and one not showing the same but yet other positive results. Let's not jump to absolute conclusions about what the latter study means.

Response from Brad Gibson PhD

Kathleen,

You make some good points, and I agree that this most recent NIA caloric restriction study needs to be considered within the context of other published work. There are undoubtedly many nuances in experimental design and interpretation that future experiments will need to address. That said, my major point is that the data for CR in primates is weak at best.  Many of my colleagues were very critical of the earlier Wisconsin study on two counts: the fact that they fed the control group a fairly high caloric diet and that they removed animals from their final analysis on the basis that they died from non age-related reasons. The removal of animals in the final statistical analysis was a very dubious call. And, as it was pointed out in the NYT article—and by many critics of the Wisconsin study—if those animals were included there was no difference in longevity between the two primate groups. Combined with other studies on more diverse genetic backgrounds in mice that show very mixed effects of CR, one really has to wonder how much traction the CR models has left in it, at least in mammals. Oddly, the data on other model organisms (flies, worms etc.) remain strong.  But one can only push these conserved evolutionary arguments so far.

While there may be benefits in a CR diet as you indicate (e.g., cancer and heart disease), one needs to make a distinction between a low calorie diet and caloric restriction. Many years ago a very prominent scientist in the field of aging who practiced the CR diet stated at the end of his seminar that "we scientists" needed to make a case to the public about the benefits of CR. I challenged him on this assertion, saying that American's relationship to food is so screwed up as it is, that to send a message that food is your enemy is not good advice. There is no evidence that CR in humans is beneficial. In contrast, there's plenty of evidence that a sound, balanced, healthy, low-to-moderate caloric diet (especially one that limits or avoid meat and dairy) is good for you. I suspect we are in agreement on that point.

I also agree that we are still far from drawing a final conclusion on the benefits of CR on human longevity. I was a bit flippant on this point in my last blog post. Guilty as charged. And there is little doubt that there will be more NIH studies examining CR and longevity in various mammalian and primate models as there is still compelling and interesting evidence that needs to be sorted when all animal models of CR and longevity are considered. However, I for one, will be placing my bets elsewhere.
Posted by
Labels: , ,
 

Sample text

Sample Text

Sample Text